Overlap in drug-disease associations between clinical practice guidelines and drug structured product label indications

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Overlap in drug-disease associations between clinical practice guidelines and drug structured product label indications

BACKGROUND Clinical practice guidelines (CPGs) recommend pharmacologic treatments for clinical conditions, and drug structured product labels (SPLs) summarize approved treatment indications. Both resources are intended to promote evidence-based medical practices and guide clinicians' prescribing decisions. However, it is unclear how well CPG recommendations about pharmacologic therapies match S...

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High-Risk Drug–Drug Interactions Between Clinical Practice Guidelines for Management of Chronic Conditions

Clinicians and clinical decision-support systems often follow pharmacotherapy recommendations for patients based on clinical practice guidelines (CPGs). In multimorbid patients, these recommendations can potentially have clinically significant drug-drug interactions (DDIs). In this study, we describe and validate a method for programmatically detecting DDIs among CPG recommendations. The system...

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Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines

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FDA drug package inserts provide comprehensive and authoritative information about drugs. DailyMed database is a repository of structured product labels extracted from these package inserts. Most salient information about drugs remains in free text portions of these labels. Extracting information from these portions can improve the safety and quality of drug prescription. In this paper, we pres...

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Multi-label classification has many applications in the text categorization, biology and medical diagnosis, in which multiple class labels can be assigned to each training instance simultaneously. As it is often the case that there are relationships between the labels, extracting the existing relationships between the labels and taking advantage of them during the training or prediction phases ...

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ژورنال

عنوان ژورنال: Journal of Biomedical Semantics

سال: 2016

ISSN: 2041-1480

DOI: 10.1186/s13326-016-0081-1